She is a strong-willed woman and not once _____ in to any difficulty in her life. [ ]

A. she has given

B. did she give

C. she gave

D. has she given

下列关于收涩药收敛作用的叙述中，错误的是

A．鞣质可固涩汗腺，引起汗液分泌减少

B．鞣质与溃疡面接触，可凝固表层蛋白质，形成保护层，减轻创面刺激

C．收涩药所含的鞣质，具有收敛作用

D．鞣质有溶血作用，外用可加重皮肤局部出血

E．以上均非