问题 单项选择题 A1/A2型题

下列对吩噻嗪类抗精神药构效关系的叙述不正确的是()

A.2位被吸电子基团取代时活性增强

B.吩噻嗪10位氮原子与侧链碱性氨基氮原子间相隔2个碳原子为宜

C.侧链上碱性氨基,可以是二甲氨基或哌嗪基等

D.吩噻嗪环10位氮原子换成碳原子,再通过双键与侧链相连接,为噻吨类抗精神病药

E.碱性侧链末端含伯醇基时,可制成长链脂肪酸酯的前药,可使作用时间延长

答案

参考答案:B

解析:以上对吩噻嗪类抗精神药构效关系正确的是2位被吸电子基团取代时活性增强。吩噻嗪10位氮原子与侧链碱性氨基氮原子间相隔3个碳原子为宜。侧链上碱性氨基,可以是二甲氨基或哌嗪基等。吩噻嗪环10位氮原子换成碳原子,再通过双键与侧链相连接,为噻吨类抗精神病药。碱性侧链末端含伯醇基时,可制成长链脂肪酸酯的前药,可使作用时间延长。所以答案为B。

阅读理解与欣赏

       为了提炼纯净的镭,居里夫妇搞到一吨可能含镭的工业废渣。他们在院子里支起了一口大锅,一锅一锅地进行冶炼,然后再送到化验室溶解、沉淀、分析。化验室只是一个废弃的破棚子,玛丽终日在烟熏火燎中搅拌着锅里的矿渣。她衣裙上,双手上,留下了酸碱的点点烧痕。一天,疲劳之极的玛丽揉着酸痛的后腰,隔着满桌的试管、量杯问皮埃尔:“你说这镭会是什么样子?”皮埃尔说:“我只是希望它有美丽的颜色。”经过三年又九个月,他们终于在成吨的矿渣中提炼出了0.1克镭。它真的有极美丽的颜色,在幽暗的破木棚里发出略带蓝色的荧光。

1.第一句话中的“可能含镭”说明    [ ]

   A.连居里夫妇自己也不知道镭这种元素究竟藏在哪里。 

   B.居里夫人对探索“其他物质有没有放射性”的执著追求和不懈努力。

   C.含镭的矿物不多。

2.从“终日”和“终于”两个词中,你读懂了什么?

                                                                                                                                        

3.玛丽和皮埃尔的对话说明他们在如此艰苦的条件下进行如此艰难的实验,不是为了                  ,而只是为了                                                    ,他们追求的目标是高远的。

阅读理解

For many people, the story of cottages — small vacation homes away from the city — is a deeply personal one. For some families, cottages have been the scene of reunions, vacations and family adventures for generations.

In North America, “cottaging(去乡间别墅度周末)” really began during the 19th century. At that time, crowds of people were moving from family farms to cities. Naturally, these people often felt a longing for the natural beauty of the countryside. Frequently located near lakes, in the mountains of woods, cottages provided a perfect solution.

Traditionally small and rustic (乡下风格的),many cottages were once simple log(原木) homes without bathrooms, water or electricity. While in most cases that is no longer true, people still go to cottages in large numbers to escape the city and to enjoy “cottage life.”

Despite the peaceful setting, there is always plenty to do at a cottage. If you enjoy outdoor activities, try hunting, boating or hiking. Many cottages are located near a lake, so you have opportunities to go swimming, boating or sunbathing around. Enjoy a picnic with your family, or build a campfire to roast hot dogs. On rainy days, curl up(蜷曲) on a comfortable chair inside and read, or enjoy board games (棋类游戏) with your friends and relatives. Want to get out and explore? Take a tour of the lake in a motorboat, or visit one of the many small villages located nearby.

Many families rent cottages instead of owning them, but for those who do, there’s always work to be done. Wood must be chopped for the stove. Leaves need to be gathered and gardens taken care of. Since many cottages are old buildings, there’s usually something that needs to be fixed or painted.

The story of cottages is one of families, traditions and memories. Are you ready to try cottaging with your family?

小题1:The underlined word “longing” in Paragraph 2 probably means “_________ ”.

A.horror

B.need

C.disappointment

D.excitement小题2:What do we know about a cottage?

A.It is far from lakes.

B.It is not popular now.

C.It was probably built of wood.

D.It was built in a short time.小题3:Which of the following does NOT belong to the activities mentioned in the text?

A.Sunbathing and swimming.

B.Hunting, hiking and boating,

C.Having a picnic and roasting hot dogs.

D.Playing football and watching games on TV.小题4:Which of the following words can best describe the author’s attitude towards“cottaging”?

A.Critical.

B.Doubtful.

C.Positive.

D.Bored.