The discovery of the new drug is of great ____ to people who suffer from heart problems.

A．appreciation

B．significance

C．satisfaction

D．guidance

( )发出工程变更的权力，一般会在施工合同中明确约定，通常在发出变更通知前应征得业主批准。

A．设计方

B．供货方

C．施工方

D．监理方