女性，44岁。10年前行二尖瓣闭式扩张，近2年行走时出现胸闷、气促。超声心动图提示二尖瓣开口面积1．0cm²，瓣膜增厚，钙化，瓣下腱索增粗、融合、缩短。该患者最适合的治疗方法是（）.

A.再次闭式扩张治疗

B.球囊扩张治疗

C.直视下二尖瓣瓣膜成形

D.药物治疗

E.人工瓣膜置换

Where shall the key to C0₂ room be kept?（）

A.In master's cabin

B.In third office's cabin

C.In a break-glass-type enclosure conspicuously located adjacent to the room

D.In a locked locker conspicuously located adjacent to the room