原发性痛风最主要的发病机制是（）
A.磷酸核糖焦磷酸合成酶活性增强
B.次黄嘌呤-鸟嘌呤磷酸核糖转移酶缺乏
C.胰岛素抵抗
D.尿酸排泄减少
E.尿酸生成增多
参考答案：D
解析：只有很少数患者是因为磷酸核糖焦磷酸合成酶活性增强或次黄嘌呤一鸟嘌呤磷酸核糖转移酶缺乏引起痛风，80％～90％原发性痛风病人都是因为肾小管排泌尿酸减少或回吸收过多发病。
| 从方框中选出适当的句子补全对话，其中有两项是多余的。 | |
| A: Hi, Zhou Qiang. Haven't seen you for too long! 1. B: I've just been to the Three Gorges (三峡). A: Really? 2. B: Right. As you know, we've built a great dam (坝) across the Changjiang River. A: 3. B: Yes, the dam is stopping water these days. And the water is rising 2 meters every day until it is 135 meters high. A: Oh, no wonder (难怪) it's said the beautiful scenery of Kuimen will be under water. What a pity! B: 4. It has been copied in another place with some other places of interest. A: Great! I want to go to the Three Gorges this summer. Would you like to go there with me again? B: I'd love to! 5.
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