They had a pleasant chat _____ a cup of coffee. [ ]

A. for

B. with

C. during

D. over

下列体征中，对诊断感染性心内膜炎最有意义的是（）

A.进行性贫血

B.脾肿大

C.皮肤黏膜淤斑、淤点

D.发热

E.新出现的病理性杂音或原有杂音明显改变