His efforts to raise money for his programme were _____ because no one showed any intention to take a cent out of their pockets.[ ]

A. in place  

B. in sight

C. in effect  

D. in vain

符合结核病以坏死为主的病变特点的是（）

A.发生在结核杆菌量多、毒力强时

B.渗出和增生性改变均可继发坏死性病变

C.坏死组织质地较实，均匀细腻

D.镜下为红染无结构物质

E.坏死结构中多含有一定量的结核杆菌