----How soon will you send the book to me?

----It will be two days _______ you receive my book.

A．before

B．that

C．since

D．when

血栓闭塞性脉管炎早期的典型症状是（）

A．肢端紫绀，发凉

B．间歇性跛行

C．肢端干性坏疽

D．下肢肌肉萎缩

E．持续性疼痛