问题 单项选择题

在类风湿关节炎的治疗中,对精子、卵子有一定损伤,出现致畸,长期应用致癌的药物为()

A.甲氨蝶呤

B.柳氮磺吡啶

C.来氟米特

D.氯喹

E.硫唑嘌呤

答案

参考答案:E

解析:

本题考查类风湿关节炎治疗药物的不良反应。治疗类风湿关节炎的药物中,硫唑嘌呤的不良反应包括皮疹,骨髓抑制,胃肠道反应,肝损害,胰腺炎,对精子、卵子有一定损伤,出现致畸,长期应用致癌;故选项E为正确答案。

甲氨蝶呤多采用每周用药1次,常见不良反应有恶心、口炎、腹泻、脱发、皮疹,少数出现骨髓抑制、听力损害和肺间质变。柳氮磺吡啶一般用药4~8周后起效,如4个月内无明显疗效,应改变治疗方案,对磺胺过敏者禁用。

来氟米特的剂量为10~20mg/d,不良反应有腹泻、瘙痒、高血压、氨基转移酶升高、皮疹、脱发和一过性白细胞下降等。氯喹起效慢,服药3~4个月疗效达高峰,至少连服6个月后才能宣布无效,且本药有蓄积作用,易沉淀于视网膜的色素上皮细胞,引起视网膜变性而致失明。

单项选择题
完形填空
完形填空
     I was on my lunch break in the city, enjoying a salad at an outdoor cafe, when a shabby homeless
lady came walking towards me.She was yelling and __1__ everyone who walked past her for spare
__2__ and she looked like a mess.My __3__reaction was fear...to close off and hope she didn't come
near me, but she did.I was on the phone and when she __4__yelling, I said, "I'm on the phone, " in the
nicest way I could, assuring myself what she needed was a lesson in __5__.She walked away, mumbling (自言自语), "I'm __6__you.I'm sorry, I'm sorry.I'll leave." And she turned the corner.__7__, I would
feel relieved or satisfied, but something in me couldn't __8__.Without another thought, I looked in my
__9__for the spare change I had.Even I started searching through my entire purse, the pockets,
everything-for all of the change I could __10__find to give.
     I got up and walked towards this lady and gave her all I __11__.She held my hand and said, "Thank
you!" Her hand was __12__and dirty, but I didn't mind __13__her hand.I wanted to be there for her for
some reason, when normally I would __14__the other way.She looked at me and said, "Will you touch
my face?" And for some reason, I did.I put my hand on her cheek and she started to __15__.I could
__16__it was as if she had not been touched by a loving, soft hand in ages,
__17__, and so I held it there, trying to __18__her with my heart open.It was powerful.She thanked me
and walked away quietly.And I walked away with an open heart, trying to__19__sense of what had just
happened.It changed something in me and has made me want to be a __20__person to the people I meet during my day.
( )1. A. greeting      
( )2. A. change        
( )3. A. usual          
( )4. A. came across    
( )5. A. attitude        
( )6. A. calling        
( )7. A. Fortunately    
( )8. A. rest        
( )9. A. car            
( )10. A. necessarily    
( )11. A. earned        
( )12. A. soft          
( )13. A. washing      
( )14. A. lead          
( )15. A. cry          
( )16. A. expect        
( )17. A. if necessary  
( )18. A. persuade      
( )19. A. take          
( )20. A. kinder        
B. praising  
B. room      
B. instant  
B. came out  
B. trouble  
B. hurting  
B. Normally  
B. appear    
B. table    
B. possibly  
B. searched  
B. rough    
B. waving    
B. set      
B. laugh    
B. sense    
B. if any    
B. comfort  
B. get      
B. richer    
C. applying      
C. clothes        
C. last          
C. came over      
C. practice      
C. annoying      
C. Luckily        
C. enjoy          
C. wallet        
C. deliberately  
C. found          
C. large          
C. wiping        
C. turn          
C. yell          
C. know          
C. if so          
C. entertain      
C. catch          
C. wiser          
D. begging        
D. food          
D. general        
D. came through  
D. manners        
D. abusing        
D. Unfortunately  
D. exist          
D. seat          
D. certainly      
D. made          
D. neat          
D. holding        
D. show          
D. shout          
D. learn          
D. if ever        
D. amuse          
D. make          
D. happier