108. Dr. Manette had been mentally ____ by his long years alone in prison and his hair had turned white.

A．disturbed

B．troubled

C．worried

D．Damaged

职业健康安全管理体系建立后，必须根据企业各项情况的改变，对现有体系制度不断地改进、补充和完善，使整改体系呈现螺旋式上升的动态过程。