队列开始时，在队列中按—定比例随机抽样作为选出一个有代表性的样本作为对照组，观察结束时，队列中出现的病例作为病例组，与对照组进行比较

A．巢式病例对照研究
B．病例队列研究
C．病例交叉研究
D．单纯病例研究
E．病例时间对照设计

There was such a long queue for coffee at the interval that we ______ gave up. [ ]

A. eventually

B. unfortunately

C. generously

D. purposefully