男性，34岁。饭后1小时突然上腹部持续性刀割样痛，阵发性加剧，查体有明显腹膜刺激征，以上腹部为著，下腹部有少量皮下淤斑。

下列哪项检查最有助于诊断（）

A.胃镜检查

B.血清脂肪酶测定

C.血清淀粉酶测定

D.腹部透视

E.心电图

Not until I began to work ________ how much time I had wasted.  [ ]

A. did I realize                  

B. didn't I realize

C. hadn't I realized          

D. had I realized