Great changes ________ in the village in the past two years.

A．have taken place

B．had taken place

C．were taken place

D．have been taken place

患儿，6岁。咳喘3小时，喉间哮鸣，咳嗽痰黏，色黄难咯，流清涕，恶寒，发热，面色红赤，夜卧不安，无汗，口渴，小便黄赤，大便干，咽红，舌红苔薄白，脉浮紧。应首选的方剂是（）

A.大青龙汤

B.麦味地黄丸

C.麻杏石甘汤合苏葶丸

D.小青龙汤合三子养亲汤

E.玉屏风散合人参五味子汤