问题 单项选择题 B型题

单胺氧化酶抑制剂并用氯丙嗪,即增强安定作用又可降压,此为()

A.作用于同一作用点或受体的相互作用

B.用于不同作用点或受体的相互作用

C.敏感化现象

D.竞争性拮抗作用

E.非竞争性拮抗作用

答案

参考答案:B

解析:

本组题考查药物相互作用知识。 竞争性拮抗剂(antagonist)只有与受体的亲和力,但没有内在活性,它与非竞争性拮抗剂的区别是与受体有无亲和力。利尿药:如氢氯噻嗪、呋塞米(速尿)、依他尼酸(利尿酸)等,都能抑制胰岛素β细胞分泌胰岛素,使甲苯磺丁脲无法发挥降糖作用,导致血糖升高,少数病人甚至会发生糖尿病性昏迷。即氢氯噻嗪和甲苯磺丁脲均作用于胰岛素p细胞,产生竞争性抑制作用,单胺氧化酶抑制剂作用于MAO-A或MAO-B受体,从而进一步影响DA,而氯丙嗪作用于DA受体,两者合用作用加强。

阅读理解

阅读理解。

     Jan. 7, 2008-French President Nicolas Sarkozy would marry his girlfriend, former supermodel Carla

Bruni on Feb. 8 or 9, media reported Monday. The report said that in December---less than a month after

Sarkozy met Bruni-he gave her a heart-shaped diamond engagement ring.

     Carla Bruni, Italian singer, former model and girlfriend of France's President Nicolas Sarkozy, holds the

hand of her son Aurelien while wearing a pink heart-shaped ring during a visit to the ancient Jordanian ruins

of Petra Jan. 5, 2008. French newspapers reported that Sarkozy would marry her early in February.

     Sarkozy and his wife of 11 years, Cecilia, divorced in October. Their marital (婚姻) problems became

well known in May 2005 when she appeared in public at the side of event organizer Richard Attias.

     A marriage to Bruni, a one-time star of the catwalks who is now a singer, would be Sarkozy's third: He

divorced his first wife, Marie, in the late 80s-after he had met and befriended Cecilia. Political analyst

Dominique Moisi said that a Sarkozy proposal to Bruni could be part of his desire to head off any future

arguments, and the speed of their visit to the ancient Jordanian ruins of Petra Jan. 5, 2008 would fit with

his personality as a busy man in a hurry.

     "Apparently, he's going to marry her, so the problem will be behind him," Moisi said. "He will increase

the opportunities to travel with her, and to say to the French, 'You see, I must remarry… You need a first

lady.'"

     Bruni, an Italian-born French citizen, has dated famous men including Mick Jagger and Donald Trump.

She has also reportedly been linked to singer Eric Clapton and actor Vincent Perez.

1. Sarkozy's second marriage was held _____.

A. in 1996

B. in May 2005

C. once he divorced Marie

D. 11 years later than the first

2. What is the correct order of Sarkozy's marital history?

a. Long marriage to Cecilia.

b. Visiting ruins with Bruni

c. Getting divorced from Marie

d. Giving Bruni a diamond ring

e. To marry the former supermodel

A. c-a-b-d-e

B. e-d-c-a-b

C. c-a-d-b-e

D. a-c-d-b-e

3. The possible purpose of the last paragraph is _____.

A. to provide some unknown stories about Bruni's love affairs

B. to show uncertainty about the former supermodel's loyalty

C. to imply that past experiences have little effect on a person

D. to prove Bruni one of the most popular and attractive females

4. Which would be the best title for the news?

A. Bruni, France's first lady

B. A third marriage to fail

C. France to have first lady

D. President's new girl friend

选择题