What is cardiac output and please describe some factors affecting the cardiac output. (10 Points)
参考答案:
Cardiac output (CO): The product of the frequency of pumping (heart rate) and the stroke volume is the cardiac output; it is also called minute volume. [1`]
Influencing factors: [9`]
(1) stroke volume (SV):
① Preload of myocardium (end-diastolic volume of ventricle, EDV), depends on heterometric regulation and Frank-Starling Law; positive correlation between the EDV and SV. (2`)
② Myocardial contractility, depends on homometric regulation and receives control of nervous or/and humoral factors, positive correlation between the myocardial contractility and SV. (2`)
③ Afterload of myocardium (arterial blood pressure , ABP), if it increases, evokes delay of isovolumic contraction period, decurtation of ejection phase, decrease of SV and remnant hypervolemia of ventricle, which results in preload increase, and then regulated by Frank-Starling Law enlarging SV. (2`)
(2) Heart rate, HR: there is positive correlation between the HR and CO with the certain range of HR (F0~AH0 bpm). HR overrun will induce decrease of CO. (2`)
(3) Myocardial compliance: It is direct ratio to myocardial contractility and increase CO. (1`)