----What did he want to know,Anne?

-----_______I could finish writing the report.

A．When was it

B．It was when that

C．It was when

D．When it was that

男，60岁，右侧肢体逐渐抖动半年余，无既往病史。体检：血压199/119mmHg，神志清楚，表情呆板，右上下肢肌力正常，肌张力增高．右上下肢可见静止性震颤，其余神经系统检查未发现异常

该病的病变原因是大脑和中脑的黑质纹状体变性，引起哪种神经介质减少而出现的一系列症状( )

A．5-羟色胺

B．乙酰胆碱

C．谷氨酸盐

D．色氨酸

E．多巴胺