问题 单项选择题

影响胆固醇吸收的药物是()

A.氯贝丁酯

B.塞伐他汀

C.烟酸

D.考来烯胺

E.普罗布考

答案

参考答案:D

解析:

考来烯胺在肠道通过离子交换与胆汁酸结合后发生下列作用:

①被结合的胆汁酸失去活性,减少食物中脂类(包括Ch)的吸收;

②阻滞胆汁酸在肠道的重吸收;

③由于大量胆汁酸丢失,肝内Ch经7α-羟化酶的作用转化为胆汁酸;

④由于肝细胞中Ch减少,导致肝细胞表面LDL受体增加和活性增强;

⑤大量含Ch的LDL经受体进入肝细胞,使血浆TC和LDL水平降低;

⑥此过程中的HMG-CoA还原酶可有继发活性增加,但不能补偿Ch的减少,若与他汀类联合应用,有协同作用。

阅读理解

Boxing was long viewed sickly. Generally forbidden by law in earlier days, the fighting was usually done with bare fists, and matches often lasted forty or fifty rounds.

In 1882 John L. Sullivan, a fighter of great power, won the world heavyweight championship from Paddy Ryan in a bare fisted battle marked by hitting, scratching, and biting without any rule. Five years later, while fighting Patsy Cardiff at Minneapolis, Sullivan broke his right arm in the third round, but he continued fighting to the sixth round and won. In 1889, Sullivan defeated Jade Kilrain with his bare fists in another championship fight, winning twenty thousand dollars and a diamond prize medal. His admirers talked then of running him for the next governor, but he traveled to Australia for a boxing tour instead, coming back only to lose his title in a twenty-one-round match with a young Californian named James J. Corbett.

“Gentleman James” victory in this match marked a turning point, for it showed scientific boxing was over strength. But Corbett’s title ended in 1897, when another boxer, Bob Fitzsimmons, in less than three seconds, achieved his feats and then Fitzsimmons knocked out an Irishman, won the heavyweight championship of the world, and invented the terrible “solar plexus punch.”

小题1: Boxing matches in the early days were ________.

A.short and bloody

B.usually spare-time competitions

C.governed by strict rules

D.cruel小题2:Sullivan held the world’s heavyweight title for ________.

A.at least seven years

B.only a year

C.five years

D.twenty-one years小题3:Sullivan’s fight with Kilrain was ________.

A.the first boxing championship match

B.a bare-fisted championship fight

C.the last boxing match to be fought bare-fisted

D.a six-round match小题4:Sullivan was so popular that his admirers ________.

A.encouraged him to be a governor

B.raised twenty thousand dollars for him

C.advised him to take boxing tour of Australia

D.refused to believe he could be defeated

单项选择题