男性，29岁，间断面部及双下肢浮肿3年。体格检查：BP140/92mmHg（18.7/12kPa），Hb98g/L，尿蛋白（++），沉渣RBC3～5/HP，颗粒管型0～2/HP，BUN10mmol/L，Scr198mmol/L。诊断为（）

A.急性肾炎

B.慢性肾炎

C.急进性肾炎

D.隐匿性肾小球疾病

E.肾病综合征

________, what she had devoted herself to resulted in nothing but failure.

A．To her much disappointment

B．To her great disappointment

C．Great to her disappointment

D．To her disappointment much