It was along the Mississippi River ________ Mark Twain spent much of his

childhood.

A．how

B．which

C．that

D．where

男性，30岁，右侧甲状腺单发结节，质硬，生长迅速，近1周伴声音嘶哑，ECT示右甲状腺冷结节。如未能确诊，拟行手术，应采用何种术式（）。

A.结节切除术

B.患侧腺体全切

C.颈部淋巴结清除术

D.患侧腺体大部切除加冰冻切片检查

E.患侧全切，峡部切除，对侧大部切除