患者一年来口腔黏膜反复起疱、破溃，此起彼伏，伴有疼痛。检查发现：口腔黏膜广泛云雾状水肿，有多处鲜红糜烂面，周围有灰白色疱膜，撕取疱膜时可同时揭去周围正常黏膜

患者还可以有以下症状，除了（）

A.出现皮损

B.吞咽困难

C.淋巴结肿大

D.指甲纵嵴

E.唾液增多

Due to a constAntly ______ environment， a poor understanding of the user’s needs and preferences，as well as a ______ of willingness to modify ______ organizational structures and decision models，the full economic potential of Web Information Systems(WIS) has not been realized by now. The data object types of the ______ meta model，the Extended World Wide Web Design Technique(eW3DT)，provide hypertext designers ______ a conceptual，user-centric framework and graphical notation for the construction of both，______ and customized models， during the software development ______ of commercial WIS. A reference model as a normative concept represents an abstraction of a ______ company，its functional units， or its(Web) Information System and is intended to streamline the design and implementation of complex applications at ______costs. As precondition for pursuing a partial globalization strategy，eW3DT ______ between technical and content-specific responsibilities for designing， implementing， and maintaining WIS.

A．give

B．above

C．presented

D．got