女性，26岁，多血质外观，向心性肥胖，痤疮，下腹及大腿外侧见紫纹，血皮质醇明显升高。为进一步诊断病变部位，哪项检查最有意义（）

A.尿游离皮质醇测定

B.血ACTH测定

C.尿17-羟测定

D.小剂量地塞米松抑制试验

E.垂体CT

— How did you sleep last night?

— Not very well. I ________ too late preparing a report for the meeting.[ ]

A. made up  

B. stayed up 

C. kept up   

D. turned up