患者女，33岁，因“体检发现血红蛋白增高4年”来诊。实验室检查：白细胞10.48×109/L，红细胞6.80×1012
/L，血红蛋白181g/L，血细胞比容0.57，血小板363×109/L。
提示骨髓活检：骨髓增生极度活跃，粒/红比例减低，巨核细胞增多，散在分布，网状纤维染色（++）。JAK2V617F（－），维生素B12230.00 pmol/L（正常值133～675 pmol/L），中性粒细胞碱性磷酸酶活性（N-ALP）阳性率为88%，阳性指数为282。B型超声：脾15.5 cm×5.6cm。为确诊，进一步检查是（）
A.JAK2第12外显子突变分析
B.MPL突变分析
C.BCR/ABL融合基因检测
D.造血细胞克隆性分析
E.染色体核型分析
F.血红蛋白电泳
参考答案：A, B, C, D, E
Sneakers are a kind of shoes worn by many people all over the world. , no one really knows where the word “sneaker” came from. Some say it came from the old English verb “sneak”, which means to move silently and quickly. The only thing we are is that when you put on a pair of sneakers, you feel light-hearted, light-footed and ready to play.  Sneakers of some kind are used by those who play tennis, basketball, and other sports. New design has been made for people who run slowly. In fact American children of ages would much rather play in sneakers than anything else. New York City once held a poetry competition for children. The subject was only “sneaker”. One prize winner called poem “The Sneaker and the World Peace”. “When everyone is wearing sneakers,” she said, “it will be impossible to .” American school children can be seen every day sneakers of all colors. They put them on in the morning and take them off at bedtime. Sneakers are washed. Some children think the older and dirtier they are, the loveable they are. When their sneakers wear out, children hate to throw them off. How do you explain the closeness between and sneakers? Perhaps another young winner in the New York Poetry Contest said it best. “A shoe is just a shoe,” he said. “But a sneaker is a friend.”
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