The monument was built in honor of the explorer who was believed＿＿the big river.

A．to have discovered

B．to have been discovered

C．to be discovered

D．having been discovered

2型糖尿病的发病与胰岛素抵抗和胰岛素分泌的相对性缺乏有关，两者皆呈不均一性。其发生发展主要分为4个阶段，下列选项中，不属于该4个阶段的是（）。

A.遗传学易感性

B.高胰岛素血症和/或胰岛素抵抗

C.糖耐量减低

D.临床糖尿病

E.免疫学异常