Why! I have nothing to confess, ____you want me to say?[      ]

A. What is it that

B. What it is that  

C. How is it that

D. How it is that

兔疥螨病的临诊表现是（）。

A.引起全身循环障碍

B.皮肤炎症、贫血、消瘦

C.皮肤受损和产生变态反应

D.消瘦、结痂、脱毛、剧痒、形成水疱或结节

E.皮肤红肿、炎症、出血