问题 单项选择题

磺胺类抗菌作用机制是()

A.抑制RNA聚合酶

B.抑制二氢叶酸还原酶

C.抑制二氢叶酸合成酶.

D.抑制拓扑异构酶IV

E.抑制肽酰基转移酶

答案

参考答案:C

解析:本题考查抗菌药物的作用机制。磺胺类药物与对氨基苯甲酸的结构相似,可与对氨基苯甲酸竞争二氢叶酸合成酶,阻止细菌二氢叶酸的合成,从而抑制细菌的生长繁殖。利福平与依赖DNA的RNA多聚酶的β亚单位牢固结合,阻止该酶与DNA连接,阻断RNA的转录过程,从而抑制细菌RNA的合成。甲氧苄啶是强大的细菌二氢叶酸还原酶抑制剂,抗菌谱与磺胺甲噁唑相似。

阅读理解

Imagine that the genome (基因组) is a book.The book consists of 23 chapters with thousands of stories made up of paragraphs, words and letters on different levels.There are one billion words in the book, as long as 800 Bibles; if I read the genome out to you at the rate of one word per second for eight hours a day, it would take me centuries; if I wrote out the human genome, one letter per millimeter, my text would be as long as the River Danube.This is a huge volume, a book of great length, but it all fits inside an extremely small cell nuclear(细胞核) that fits easily upon the head of a pin.

The idea of the genome as a book is not, strictly speaking, even a metaphor.It is true to a great extent.A book is a piece of digital information, written in one-directional form and defined by a code that translates a small alphabet of signs into a large dictionary of meanings through the order of their groupings.So is a genome.The only difference is that all English books read from left to right, while some parts of the genome read from left to right while some from right to left, but never both at the same time.

While English books are written in words of different lengthens using twenty-six letters, genomes are written entirely in words of three-letter length, using only four letters, and instead of being written on flat pages, they are written on long chains of DNA molecules (分子).

The genome is a very clever book, because in the right condition it can both photocopy itself and read itself.

小题1:How do human genomes read according to the passage?___________

A.Only from left to right.

B.Only from right to left.

C.From both directions at the same time.

D.From one direction at a time.小题2:We can learn from the passage that the human genome ________.

A.is as long as the River Danube

B.can be easily placed on the head of a pin

C.is coded with an alphabet of four letters

D.is smart enough to read and take photos of itself小题3:It can be concluded that the passage is mainly written for ______.

A.specialists in the field

B.general readers

C.natural scientists

D.readers with professional knowledge小题4:The real purpose of the author’s comparison of the genome to a book is _____.

A.to focus on the differences between the two

B.to lay emphasis on the similarities between the two

C.to simplify the concept of the human genome

D.to give an exact description of the human genome

单项选择题