问题 单项选择题 B型题

抑制细胞对LDL的修饰()

A.烟酸

B.环丙贝特

C.考来替泊

D.洛伐他汀

E.普罗布考

答案

参考答案:E

解析:5.他汀类药物主要用于杂合子家族性和非家族性Ⅱa、Ⅱb和Ⅲ型高脂血症,也可用于2型糖尿病和肾病综合征引起的高胆固醇血症。贝特类既有调血脂作用也有非调脂作用。调血脂作用为降低血浆TG、VLDL-C、TC、LDL-C,升高HDL-C。普罗布考为疏水性抗氧化剂,抗氧化作用强,进入体内分布于各脂蛋白,被氧化为普罗布考自由基,阻断脂质过氧化,减少脂质过氧化物的产生,减缓动脉粥样硬化病变的一系列过程。同时,普罗布考能抑制HMG-CoA还原酶,使胆固醇合成减少,并能通过受体及非受体途径增加LDL的清除,血浆LDL-C水平降低;通过提高CE转移蛋白和apo E的血浆浓度,使HDL颗粒中胆固醇减少,HDL颗粒变小,提高HDL数量和活性,增加HDL的转运效率,使胆固醇逆转运清除加快。烟酸降低细胞cAMP的水平,使脂肪酶的活性降低,脂肪组织中的TG不易分解出FFA,肝合成TG的原料不足,减少VLDL的合成和释放,也使LDL来源减少。考来替泊属于胆汁酸结合树脂,此类药物进入肠道后不被吸收,与胆汁酸牢固结合阻滞胆汁酸的肝肠循环和反复利用,从而大量消耗胆固醇,使血浆TC和LDL-C水平降低。

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Is there a “success personality”—some winning combination of qualities that leads almost inevitably (必然地) to achievement? If so, exactly what is that secret success formula(公式), and can anyone develop it?
At the Gallop Organization we recently focused in depth on success, inquiring into the attitudes of 1500 distinguished people selected at random from Who’s Who in America. Our research finds out a number of qualities that occur regularly among top achievers. Here is one of the most important, that is common sense.
Common sense is the most widely possessed quality of the people surveyed. Seventy-nine percent award themselves a top score in this quality. And 61 percent say that common sense is very important in contributing to their success.
To most, common sense means the ability to present sound, practical judgments on everyday affairs. To do this, one has to remove extra ideas and get right to the key points of what matters. A Texas oil and gas businessman puts it this way: “The key ability for success is simplifying. In conduction of meeting and dealing with industry reducing a complex problem to the simplest term is highly important.”
Is common sense a quality a person is born with, or can you do something to increase it? The oil man’s answer is that common sense can definitely be developed. He owes this to learning how to debate in school. Another way to increase your store of common sense is to observe it in others, learning from their—and your own—mistakes.
Besides common sense, there are many other factors that influence success: knowing your field, self-reliance, intelligence, the ability to get things done, leadership, creativity, relationships with others, and of course, luck. But common sense stands out. If you develop these qualities, you’ll succeed. And you might even find yourself listed in Who’s Who someday.
Secrets to success
Finding of the 小题1:________
Top achievers have some common 小题2:______, one of which is common sense.
The most important quality
79 percent of the people surveyed 小题3:______ highly of common sense. And 61 percent say their success小题4:_______ from this quality.
Understanding of common sense
To most, it means one is小题5: ________ to present sound, make practical judgments on everyday affairs by小题6:________ on what really counts.
小题7:________ to get common sense
小题8:________ it through activities like learning how to debate in school. Increasing it through mistakes by observing others.
Other factors leading to success
小题9:_______ from common sense, many other factors contribute to success, luck小题10:________. But common sense is the most outstanding.
 
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