问题 单项选择题 B型题

与其他抗真菌药无交叉耐药性的棘白霉素类抗真菌药是()。

A.两性霉素B

B.卡泊芬净

C.氟胞嘧啶

D.阿糖胞苷

E.酮康唑

答案

参考答案:B

解析:

1.酮康唑可抑制肝药酶CYP3A4,药物相互作用多。

2.两性霉素B的肾毒性较大,限制其临床应用,经过改造,开发出了脂质体两性霉素B,在两性霉素B分子的外面包裹了生物脂质体,其进入体内可直接结合至真菌的感染灶,在吸附于真菌细胞膜表面后,真菌产生的磷脂酶能水解其中的脂质,使两性霉素B逸出。渗入机体,并以高浓度集中于该处组织,杀灭真菌。

3.棘白菌素抗真菌药主要有卡泊芬净、米卡芬净,和其他抗真菌药物之间无交叉耐药,因此对唑类药耐药的真菌仍有效;耐受性好,不良反应少,药物相互作用少。

阅读理解

阅读理解。

     A good education is very important for the healthy development of a child. But the way in which education is understood has changed completely. In the past, stern and rough ways were used to bring up a child, and unfeeling rules were supposed to create the excellent personality of the typical gentleman. Nowadays, society is much more open-minded and it does not put a great value on being so strict with children although this doesn't mean that opinions regarding this subject do not differ.

     On the one hand, there are those in favor of a strict teacher and the narrow-minded people who consider that only a rough hand is able to properly educate a child. Firstly, according to them, children should fear their teachers, as this is the only way in which they will pay attention. In addition to that, they think that a pupil will never learn because he enjoys doing so and takes interest in what he is doing, but only because that is what he is supposed to do if he doesn't want a low grade.

     On the other hand, there are people who believe that only by having a friendly attitude and listening to the opinions of their pupils can a teacher do his job at a high standard. Their opinion is that there has to be a connection between teachers and students before any satisfying result can be achieved. Luckily, more and more teachers understand this fact and are doing their best to get over the strict rules and get in touch with their students.

      However, this does not mean that a teacher shouldn't be a bit tougher when he feels that things are getting out of hand. All in all, I must say that a good teacher is a teacher that has the ability to be kind and strict at the same time, thus winning the respect and interest of his students.

1. Which of the following words can replace the underlined word "stern" in the first paragraph?

A. Strict

B. Ridiculous

C. Unhealthy

D. Impolite

2. Narrow-minded people think that students will only learn because of _____.

A. their interest in knowledge

B. their desire to get high marks

C. their dislike of teachers

D. their parents' will

3. Which of the following is NOT an opinion held by people who believe a teacher should be friendly?

A. Teachers should lower the standards for students

B. Teachers should have a kind attitude to students

C. Teachers should pay attention to their students' opinions

D. Teachers should often communicate with students.

4. According to the author, a teacher should ______.

A. always be tough and strict

B. always be kind and soft

C. often be kind, but be strict if necessary

D. often be strict, but be kind if necessary

单项选择题