The drug did not ________ his health; in fact, it seemed to have no ________ on him at all. [ ]

A. effect; affect      

B. effect; effect  

C. affect; effect    

D. affect; affect

（）是施工项目的最高责任人和组织者，是决定施工项目盈亏的关键性角色。

A.项目技术负责人

B.质量员

C.安全员

D.项目经理