问题 单项选择题

服用巴比妥类药物时,如果碱化尿液,则其在尿中

A.解离度增高,重吸收减少,排泄加快

B.解离度增高,重吸收增多,排泄减慢

C.解离度降低,重吸收减少,排泄加快

D.解离度降低,重吸收增多,排泄减慢

E.排泄速度不改变

答案

参考答案:A

解析: 本题考查药物的体内过程的有关内容。 苯巴比妥、海索比妥等巴比妥类药物为弱酸,在体液(pH7.4)中,有近50%或更多以分子型存在,能透过血脑屏障,到达中枢,因此具有活性。故碱化尿液,会增加药物的解离。服用时并给碳酸氢钠或乳酸钠碱化尿液,减少在肾小管中的重吸收,加速药物排泄。

阅读理解

I was being interviewed by a senior manager for a big company, I told him honestly that the principal reason that I was interviewing with them was my need to keep my family in Boston. My wife had recently died of a heart attack. A job in Boston would help me reduce some pain for my 16-year-old daughter and me. It was important to me to keep her present high school.

Bruce, the interviewer, was politely kind, but he didn’t search any further. He acknowledged(承认) my loss and, with great respect, moved on to another subject. After the next round of interviews, Bruce took me to lunch with another manager. Then he asked me to take a walk with him. He told me that he had lost his wife. And, like me, he had also been married 20 years and had 3 children. I realized that he had experienced the same pain as I had and it was almost impossible to explain to someone who had not lost a loved one. He offered his business card and home phone number and suggested that, should I need help or just want someone to talk to, I should feel free to give him a call. Whether I got the job or not, he wanted me to know that he was there if I ever needed help.

From that one act of kindness, when he had no idea if we could ever see each other again, he helped our family deal with one of life’s greatest losses. He turned the normally cold business interview process into an act of caring and supporting for another person in a time of extreme need.

小题1:According to the passage, the interviewer, Bruce, was very _______.

A.generous

B.kind

C.happy

D.mean小题2:The underlined word "principal" in the first paragraph probably means _____.

A.main

B.unimportant

C.necessary

D.possible小题3:Which of the following statement is NOT true?

A.The writer’s daughter was studying in Boston at that time.

B.Both the writer and the interviewer experienced the same pain.

C.Bruce was a senior manager of a big firm.

D.Bruce wanted to make friends with him because he gave him his business card and home phone number.

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