— I'm sorry I didn't make it to your party last night.  

—  ____. I know you are busy these days.   [ ]

A. Of course.      

B. No kidding.  

C. That's all right.    

D. Don't mention it.

女性，36岁，肥胖1年就诊。体检：满月面，皮肤多痤疮，毛发浓密，唇周有小量胡须，颈 部脂肪垫厚，血压150/100mmHg。

哪项体征是皮质醇增多症诊断的重要线索

A．高血压

B．皮肤宽大紫纹

C．水牛背

D．骨质疏松