问题 单项选择题

下列有关莨菪类药物构效关系的叙述中,错误的是

A.引入6β-羟基可使药物的中枢作用降低

B.这类药物的极性大小顺序为山莨菪碱>阿托品>东莨菪碱

C.经季铵化修饰后,中枢作用增强

D.这类药物的中枢作用强弱顺序为东莨菪碱>阿托品>山莨菪碱

E.在托品烷的6,7位引入一个环氧基,可增强中枢作用

答案

参考答案:C

解析:季铵化的药物在体液中以离子态存在,不易进入血-脑脊液屏障,中枢作用减小。

阅读理解

Alice Walker makes her living by writing, and her poems, short stories, and novels have won many awards and fellowships for her. She was born in Eatonton, Georgia. She went to public schools there, and then to Spelman college in Atlanta before coming to New York to attend Sarah Lawrence college, from which she graduated in 1966. For a time she lived in Jackson, Mississippi, with her lawyer husband and a small daughter. About Langston Hughes, American Poet, here first book for children, she says, “After my first meeting with Langston Hughes I vowed I would write a book about him for children someday. Why? Because I, at 22, knew next to nothing of his work , and he didn’t scold me; he just gave me a stack of his books. And he was kind to me; I will always be grateful that in his absolute warmth and generosity he fulfilled my deepest dream ( and need) of what a poet should be.?”

“To me he is not dead at all. Hardly a day goes by that I don’t think of him or speak of him. Once, just before he died, when he was sick with the flu, I took him a sack full of oranges. The joy I felt in giving that simple gift is undiminished by time. He said he liked oranges, too.”

小题1:What is the main topic of the passage?

A.Alice Walker’s reflection on Langston Hughes.

B.The influence of Alice Walker on the writing of Langston Hughes.

C.Langston Hughes’ book about Alice Walker.

D.A comparison of the childhoods of Alice Walker and Langston Hughes.小题2:In the passage, Alice Walker is described as _____.

A.a research fellow at Spelman College

B.a professor at Sarah Lawrence College

C.a prize-winning writer of prose and poetry

D.an author of plays for children小题3:Before attending college, Alice Walker went to school in _____.

A.Atlanta, Georgia

B.Eatonton, Georgia

C.Jackson, Mississippi

D.Lawrence, Massachusetts小题4:The word “vowed” the first paragraph is closest in meaning to _____.

A.shouted

B.believed

C.refused

D.promised小题5:It can be inferred from the passage that Alice Walker was 22 years old when _____.

A.she moved to Jackson, Mississippi

B.she moved to New York

C.she first met Langston Hughes

D.Langston Hughes died

单项选择题