ICU感染的危险因素包括（）。

A.病人的病情重

B.侵入性操作多

C.抗菌药应用不足

D.环境拥挤

E.病人周转快

— Have you decided             for your vacation?

— I'll probably go to Brighton. [ ]

A.what to spend

B.when to go

C.where to go

D.how to spend