It was after he had worked on the project for months _____ he found how to solve the problem efficiently. [ ]

A. that

B. when

C. until

D. as

哪种物质直接作用于体温调节中枢引起发热

A．病原体产生的外源性致热原

B．病原体产生的内源性致热原

C．血液中白细胞产生的外源性致热原

D．血液中白细胞产生的内源性致热原

E．血液中白细胞及病原体的代谢产物