________ 200BC, the Silk Road, which was the route for trade between the East and the West, was in use.

A．As early as

B．As far as

C．As long as

D．As well as

患者，女，15岁，因车祸致右踝以下足严重损伤，骨科医生判断损伤部位组织无法修复存活，需要进行小腿截肢。

小腿截肢理想的部位是（）

A.右踝关节处

B.小腿中下1／3处

C.小腿1／2处

D.小腿中上1／3处

E.膝关节下1／4处