根据《药品注册管理办法》的规定，对已批准上市的药品改变原注册事项的申请是（）。

A.补充申请

B.再注册申请

C.新药申请

D.仿制药申请

An ultimate purpose of learning a foreign language in a Grammar-Translation classroom is to enable the learners to （）.

A. think and communicate in the target language

B. get a practical command of the four basic skills of the language

C. get the same types of abilities that native speakers have

D. read and translate its literature