既往有哮喘病的甲状腺功能亢进病人，下列各项中，哪种药物不宜使用（）

A.丙硫氧嘧啶

B.甲硫氧嘧啶

C.卡比马唑

D.普萘洛尔

E.甲巯基咪唑

I was shocked ______ the cruelty of Tom, a relative of my wife, who not only shouted ____ the

poor man begging for something to eat but also let his violent dog come _____ him. [ ] 

A. at; at; at

B. with; to; at

C. by; to; at

D. for; at; to